FALL

5402    GENERAL HISTOLOGY / General histology and microscopic anatomy of the four basic tissues. Laboratory study of electron micrographs and computerized images is employed. Opperman - 3 sem. hrs.

5603    GROSS ANATOMY / Conceptual and functional basis for understanding the macroscopic structure of the human body utilizing laboratory dissection of human cadavers. Regional anatomy of the back, thorax, upper limb and head is emphasized.  Wang - 4 sem. hrs.

5307    CELLULAR AND MOLECULAR BIOLOGY /  Intermediary metabolism of protein, protein synthesis, nucleic acid metabolism and biochemical endocrinology. Groppe -2 sem. hrs.

5221    RESEARCH DESIGN AND METHODOLOGY / An introduction to the research process; sufficient background in research design and methodology is provided to enable students to critically evaluate literature and assist in the formulation of research projects. Also includes discussion of rules and regulations for human and animal research. Buschang - 2 sem. hrs.

5244    ADVANCED BIOLOGY OF MINERALIZED TISSUES / Overview of the advanced biology of mineralized tissues and their roles in oral health and disease.  The course will cover the basic molecular biology of teeth and the skeleton, including bone and cartilage. Other aspects of systemic biology will be explored, such as local and systemic factors that control calcium and phosphate balance, as well as recent advances in molecular biology and research methodologies (molecular biology, gene targeting and histology at both light and electron microscopic levels) for mineralized tissue research.  Taught every other year.  Feng - 2 sem. hrs.

5251    IMMUNOLOGY / Update on the principles of immunology with an emphasis on oral aspects and related diseases. Newman - 2 sem. hrs.

5V69    GROWTH AND MECHANISMS OF DEVELOPMENT / Normal prenatal growth and development. Patterns and mechanisms of growth and maturation.  Ruest - 1 sem. hr.

5V73    ADVANCED HUMAN CRANIOFACIAL DEVELOPMENT AND CRANIOFACIAL ANOMALIES / Detailed investigation of the basic processes and mechanisms of postnatal growth and adaptation of the craniofacial region.  This course emphasizes the areas of controversy surrounding the current understanding of the factors influencing postnatal craniofacial growth and form, the adaptive capabilities of growth and form, the adaptive capabilities of craniofacial tissues, the effect of altered function on craniofacial growth and form, and the influence of treatment on craniofacial growth and form.  Also considered are theories of craniofacial growth.  Buschang - 1 sem. hr.

5V81    SEMINAR: CURRENT ISSUES IN BONE AND MINERALIZED TISSUE BIOLOGY / Topics of current importance in bone and mineralized tissue biology. Dechow - 1 sem. hr.  (also given in the Spring)

SPRING

5301    NEUROSCIENCE / Lectures and laboratory sessions on gross and microscopic anatomy of the human central and peripheral nervous system. Neurophysiology of the central nervous system, peripheral nerves, special sense, autonomics and clinical mediation. Benson - 2 sem. hrs.

5205    ORAL HISTOLOGY / Origin and development of the dental tissues and their related structures. Current publications and research reports are used to provide students with an opportunity to investigate some phase of active interest to them and their anticipated future interest in practice. Svoboda - 3 sem. hrs.

5611    MAMMALIAN PHYSIOLOGY / Basic physiological principles of cells, muscle, nerve, blood, heart, circulation, respiration, digestion, excretion, and central nervous system in maintaining homeostasis. Classical laboratory experiments are used to demonstrate these principles. Ruest - 4 sem. hrs.

5222    APPLIED BIOSTATISTICS / Overview of applied biostatistics with an emphasis on oral health research. Training includes computer-based instruction in data analysis using SPSS. Schneiderman - 2 sem. hrs.

5126    RESPONSIBLE CONDUCT IN BIOMEDICAL RESEARCH / Svoboda - 1 sem. hr.

5127    MICROSCOPY, IMAGING, AND ASSOCIATED TECHNIQUES / Principles and methods of microscopy including the usage of scanning electron, light, fluorescent, and confocal microscopes, and computer imaging techniques. Varanasi - 2 sem. hrs.

5V40    CELLULAR AND MOLECULAR BIOLOGY OF ORAL AND CRANIOFACIAL TISSUES I/ Prerequisites: 5208 or equivalent; 5306 or equivalent. A general survey intended to provide background information concerning the methods and theory of modern cellular/molecular biology. This course lays the groundwork for more advanced study, aids those interested in incorporating cellular/molecular approaches into their research work and enables one to read, understand and evaluate current scientific literature. Qin - 2 sem. hrs.  Variable

5V42    CELLULAR AND MOLECULAR BIOLOGY OF ORAL AND CRANIOFACIAL TISSUES II / Processes of epithelial-mesenchymal interaction as related to odontogenesis, amelogenesis, dentinogenesis, collagen formation, intracellular and extracellular calcium homeostasis, plaque and calculus and wound healing.  Opperman/Liu -  1 sem. hr.   Variable

5350    ORAL MICROBIOLOGY / Prerequisites: 5208, 5210 or equivalent. The environment of the mouth is described and its relation to the endogenous and exogenous oral microbiota; relationship between disease and bacterial species; discussion of species differences; molecular mechanisms of bacterial pathogenesis; and host response to oral microbes. Ezzo - 3 sem. hrs.

5263    SENSORY NEUROBIOLOGY AND PAIN / An overview of the various sensory systems is explored with the primary emphasis on the processing of pain and temperature information from the craniofacial complex.  Taught every other year. Tao - 1 sem. hr.

5V75    PHYSICAL GROWTH AND MATURATION / Patterns and mechanisms of postnatal growth and maturation. Buschang - 0.5 sem. hr.

5V81    SEMINAR: CURRENT ISSUES IN BONE AND MINERALIZED TISSUE BIOLOGY / Topics of current importance in bone and mineralized tissue biology. Faculty - 1 sem. hr.  (also taught in the Fall)

5190    SEMINAR: CURRENT ISSUES IN SCIENCE / Guest lectures, workshop lectures and discussion; includes topics of current interest to program faculty and students and of general interest in the biomedical sciences. Opperman - 1 sem. hr.

SUMMER

5V04    HEAD AND NECK ANATOMY / Special emphasis on surgical anatomy and distribution of nerves and vasculature of particular interest in the field of dentistry. Wang - 1.5 sem. hrs.

5208    MICROBIOLOGY / Introduction to basic microbiology with emphasis on oral and medical microbes, taxonomy and microbial physiology. Taught in conjunction with dental curriculum. Additional readings and discussion for graduate students. Honeyman - 3 sem. hrs.

5312    APPLIED MEDICAL PHYSIOLOGY / Prerequisite: 5611 or equivalent. Basic physiology of the cardiovascular, respiratory and renal systems. Each area is expanded to include physiology problems seen clinically as they relate to the dental intern. Bellinger - 2 sem. hrs.

5214    CLINICAL PHARMACOLOGY.  Selection and evaluation of dentally related drugs and review of current literature; seminar format.  Limited to clinical specialty students.  Roesch - 1.5 sem. hrs.

5341    TECHNIQUES IN CELL AND MOLECULAR BIOLOGY / Principal methods of cellular/molecular investigation of proteins and nucleic acids including immunocytochemistry, western blotting, northern/southern blotting, radioimmunoassay, in situ hybridization, polymerase chain reaction, intracellular recording and fluorescence confocal microscopy.  Lu - 1 sem. hr.

FALL, SPRING, SUMMER

5V91  SPECIAL TOPICS IN ORAL BIOLOGY / Reading and discussion of current literature pertinent to the topic of the seminar.  Presentation of papers on selected topics is required for all students.  May be used for multiple courses in any one semester.  Faculty.  Variable

5V92  CURRENT TOPICS IN ORAL BIOLOGY / Faculty.  Variable

5V93, 5V94, 5V95  DIRECTED READINGS / Individualized courses for single students involved in in-depth study of specific topics in the biomedical sciences. Faculty.  Variable

5V96, 5V97 RESEARCH AND SPECIAL PROBLEMS / Concentrated investigation in any area of biomedical sciences. This course is appropriate for individualized laboratory rotations or research. Faculty.  Variable

5V98    THESIS RESEARCH AND PREPARATION OF MASTER'S THESIS /  Faculty.  Variable.

5V99    DISSERTATION / Course used by students after achieving candidacy for research and preparation of Ph.D. dissertation. Faculty.  Variable.